SciELO - Scientific Electronic Library Online

vol.36 número1Prophylaxis with levofloxacin: impact on bacterial susceptibility and epidemiology in a hematopoietic stem cell transplant unitSeroprevalence of HTLV-1/2 among blood donors in the state of Maranhao, Brazil índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Revista Brasileira de Hematologia e Hemoterapia

versão impressa ISSN 1516-8484


GOMES, Alessandra Oliveira Ferrari et al. Early and late oral features of chronic graft-versus-host disease. Rev. Bras. Hematol. Hemoter. [online]. 2014, vol.36, n.1, pp.43-49. ISSN 1516-8484.


Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.


The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation.


This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year).


Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation.


Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation.

Palavras-chave : Chronic disease; Hematopoietic stem cell transplantation; Diagnosis, oral; Graft-versus-host disease.

        · texto em Inglês     · Inglês ( pdf )