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Brazilian Archives of Biology and Technology

On-line version ISSN 1678-4324


ESTIVALLET, Hidê Virgínia; RODRIGUES, Maria Inês  and  MARRONI, Norma Possa. Effect of intragastric ethanol and hydrogen peroxide in frog gastric mucosa (Rana catesbeiana, SHAW). Braz. arch. biol. technol. [online]. 1998, vol.41, n.1, pp.55-66. ISSN 1678-4324.

This work investigated the frog gastric mucosa response to hydrogen peroxide  and ethanol   induced injury. Acid and mucus secretion were estimated "in vitro" in control animals with intragastric absolute ethanol (1ml/30min. or 2ml/60min.) and hydrogen peroxide. The gastric mucosa morphological conditions were assessed "in vivo", concerning lesion area, pH and mucus. Ethanol (1ml/30min.)  was observed to cause hyperemia, cell damage, rupture, edema, erosions, necrosis in gastric mucosa and significant increase in acid secretion. Absolute ethanol (2ml/60min.) caused a decrease in acid secretion due to alcalinization  and an increase of mucus and pH. Intragastric hydrogem peroxide provoked gastric unwrinkling and hyperemia, acid secretions were not increased, mucus fragmented and the pH was decreased. The results indicate an increase of mucus and acid in response to ethanol and unwrinkling and hyperemia to hydrogen peroxide.

Keywords : Gastric acid secretion; mucus; ethanol; hydrogen peroxide; frog.

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