Abstract

SOUSA, Andreza de  and  SOUSA, Edésia Martins Barros de. Ordered mesoporous silica carrier system applied in nanobiothecnology. Braz. arch. biol. technol. [online]. 2005, vol.48, n.spe2, pp. 243-250. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132005000700036.

Ordered mesoporous materials like SBA15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). This particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. The characteristics of SBA-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. The calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. The modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. Aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.

Keywords : Mesoporous materials; drug delivery system; cancer treatment; SBA15.