SciELO - Scientific Electronic Library Online

vol.49 issue2Dietary vitamin E supplementation on cholesterol and cholesterol oxides of pig meat and cooked hamPharmacological studies of Cordia salicifolia Cham in normal and diabetic rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Archives of Biology and Technology

On-line version ISSN 1678-4324


HOLANDA, Cecília Maria de Carvalho Xavier et al. Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats. Braz. arch. biol. technol. [online]. 2006, vol.49, n.2, pp.207-214. ISSN 1678-4324.

The aim of this work was to study the effect of antimalarial drugs on the bioavailability of 99mTc-MDP in rats. Mefloquine (MQ) and artemisinin (AM) were administered in two treated groups (T) and sorbitol in control group (C) for 7 days. Then, 99mTc-MDP was injected in all groups and %ATI was calculated. A significant increase of %ATI in MQ group, from C to T, occurred in spleen (0.35±0.10to0.58±0.13), liver (1.69±0.28to3.31±0.07) and blood (0.79±0.17to2.09±0.53). The %ATI increased significantly in AM group:femur (2.76±0.59to5.98±0.70), liver (1.69±0.28to4.59±0.68), lungs (0.29±0.05to6.22±0.86), spleen (0.35±0.10 to0.86±0.15) and blood (0.79±0.17 to4.65 ±0.74). A significant decrease of %ATI occurred in MQ group:bladder (0.75±0.07to0.26±0.05), stout bowel (2.13±0.34to0.66±0.19), pancreas (0.87±0.24to0.28±0.18), kidneys (7.00±1.52to3.46±0.62), brain (0.27±0.08to 0.05±0.01) and also in AM group:bladder (0.75±0.07to0.30±0.05), stout bowel (2.13±0.34to0.36±0.08), muscle (2.04±0.39to0.26±0.06), pancreas (0.87±0.24to0.46±0.12) and kidneys (7.00±1.52to4.35±0.28). These results could be associated to biological effects of antimalarial drugs.

Keywords : Drug interaction; radiopharmaceuticals; 99mTc-MDP; antimalarial drugs; mefloquine; artemisinin.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License