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Brazilian Archives of Biology and Technology

versão impressa ISSN 1516-8913versão On-line ISSN 1678-4324

Resumo

GAYOSO, Carla Wanderley et al. Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis. Braz. arch. biol. technol. [online]. 2006, vol.49, n.4, pp.661-664. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132006000500016.

This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg/mL for 3,4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200µg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.

Palavras-chave : Onychomycosis; fungi; maleimides; antifungical activity.

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