Abstract

TAKAHACHI, Gisele et al. Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova. Braz. arch. biol. technol. [online]. 2006, vol.49, n.6, pp. 897-903. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132006000700006.

The objective of this work was to evaluate biochemical parameters in Paracoccidioides brasiliensis infected mice and the effect of Canova medicine on these parameters. Mice infected with the isolate Paracoccidioides brasiliensis Pb18 and treated with Canova for 17 weeks were used. The biochemical parameters analysed were the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and amylase, and the concentration of total proteins, albumin and globulins. The results suggested that the animals that were treated with Canova had less functional alterations in their internal organs.

Keywords : Paracoccidioidomycosis; biochemical profile; Canova; Paracoccidioides brasiliensis.