Brazilian Archives of Biology and Technology
On-line version ISSN 1678-4324
TEIXEIRA, Gerlinde Agate Platais Brasil et al. Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease. Braz. arch. biol. technol. [online]. 2009, vol.52, n.3, pp.601-609. ISSN 1678-4324. http://dx.doi.org/10.1590/S1516-89132009000300012.
Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time dependent alterations of the gut similar to celiac disease. In conclusion, results suggested that this experimental model was a convenient tool to study the evolution of alterations in chronic antigen specific gut inflammatory process.
Keywords : Food allergy; peanuts; inflammatory bowel disease; rats; mice.