Brazilian Archives of Biology and Technology
On-line version ISSN 1678-4324
SIDER, Lucia Helena; HUCKE, Erica Engelberg Teixeira da Silva and FELICIO, Luciano Freitas. Modulation of post-coital dopaminergic tone by prior parity. Braz. arch. biol. technol. [online]. 2010, vol.53, n.3, pp.615-622. ISSN 1678-4324. http://dx.doi.org/10.1590/S1516-89132010000300015.
The aim of this study was to investigate the possible effects of reproductive experience on dopaminergic profile in three different brain tissues, hypothalamus, striatum and cortex in rats on 7th-8th day of pregnancy during the light-dark shift (between 1700-1900h). Results showed that in hypothalamus, dopamine levels increased and DOPAC/DA decreased as a function of parity. In cortex, no differences were observed. In striata, the haloperidol-induced HVA and HVA/DA increases were less intense in experienced animals. These findings suggested that reproductive experience produced functional central changes during pregnancy, with different neurochemical responses depending on the brain region.
Keywords : hypothalamus; striatum; cortex; haloperidol; HVA; DOPAC.