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Brazilian Archives of Biology and Technology

On-line version ISSN 1678-4324


SIDER, Lucia Helena; HUCKE, Erica Engelberg Teixeira da Silva  and  FELICIO, Luciano Freitas. Modulation of post-coital dopaminergic tone by prior parity. Braz. arch. biol. technol. [online]. 2010, vol.53, n.3, pp.615-622. ISSN 1678-4324.

The aim of this study was to investigate the possible effects of reproductive experience on dopaminergic profile in three different brain tissues, hypothalamus, striatum and cortex in rats on 7th-8th day of pregnancy during the light-dark shift (between 1700-1900h).  Results showed that in hypothalamus, dopamine levels increased and DOPAC/DA decreased as a function of parity.  In cortex, no differences were observed.  In striata, the haloperidol-induced HVA and HVA/DA increases were less intense in experienced animals. These findings suggested that reproductive experience produced functional central changes during pregnancy, with different neurochemical responses depending on the brain region.

Keywords : hypothalamus; striatum; cortex; haloperidol; HVA; DOPAC.

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