Abstract

WYPYCH, Thaiz Cristina  and  ANDREAZZA, Itamar Francisco. Development and evaluation of a hydrophilic matrix as a buccoadhesive system containing diclofenac sodium. Braz. arch. biol. technol. [online]. 2011, vol.54, n.5, pp. 893-900. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132011000500006.

The aim of this work was to study the development and evaluation of a hydrolphilic matrix as a buccoadhesive system containing diclofenac sodium. Eleven formulations were prepared containing the following bioadhesive polymers: hydroxylpropylmethylcellulose, polycarbophil, guar gum and xanthan gum individually and in combination. All the formulations were evaluated for the swelling index, adhesive index, and the time of adhesive and drug release profile (%). The results showed that the formulations that presented the most swelling index were the F3 (PAA/GX) and F6 (GG/GX). The smaller index swelling was for F1 (PAA/CM) and F10 (HPCMC/CM). The F4 (PAA/HPMC) formulation presented the best adhesive index and F10 (HPMC/CM) the worst. F1 (PAA/CM) was the best matrix hydrophilic adhesive for controlled release. The hydroxylpropylmethylcellulose, guar and xanthan gum when used individually presented low adhesiveness.

Keywords : Diclofenac sodium; buccoadhesive systems; guar gum; xantan gum; hydroxypropylmethyl cellulose; polycarbophil.