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Brazilian Archives of Biology and Technology

On-line version ISSN 1678-4324

Abstract

FERREIRA, Aline Siqueira et al. Xylitol inhibits J774A.1 macrophage adhesion in vitro. Braz. arch. biol. technol. [online]. 2011, vol.54, n.6, pp.1211-1216. ISSN 1678-4324.  http://dx.doi.org/10.1590/S1516-89132011000600017.

The aim of this work was to evaluate the effect of xylitol on J774A.1 macrophage adhesion. Adhesion consisted of a three-hour interval, at room temperature, followed by washing and cell incubation at 37ºC/5% CO2/ 48h. Xylitol was used to treat the cells either before (for 24h) or after the cell incubation (for 48h) at 5% as final concentration in both the situations. It was found that xylitol was effective in preventing the adhesion in both the conditions in spite of the former being 100-fold greater and significant (p < 0.001). The results pointed to an important xylitol action on macrophage adhesion, which should be further investigated as an inflammatory control.

Keywords : adhesion; J774A; 1 macrophages; xylitol.

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