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Brazilian Archives of Biology and Technology
On-line version ISSN 1678-4324
CHIOCA, Lea Rosa et al. Sodium fluoride does not alter sperm production or sperm morphology in rats. Braz. arch. biol. technol. [online]. 2012, vol.55, n.2, pp.257-262. ISSN 1678-4324. http://dx.doi.org/10.1590/S1516-89132012000200011.
The aim of the present study was to evaluate the effects of sodium fluoride (NaF) on the male reproductive system. Adult male rats were exposed to NaF in drinking water for 30 days at three concentrations: 1.54 (control, tap water), 50 and 100 ppm. Body and organ weights, daily sperm production, sperm number and morphology were investigated. No difference was observed on the sperm number and morphology among the groups, as well as body weight and organ absolute and relative weights. Overall, despite the presence of a mild degree of dental fluorosis in the higher dose group, the results indicated that exposure to NaF at the doses used in the present study did not adversely affect sperm production and morphology of male rats.
Keywords : Fluoride; sodium fluoride; male rats; reproductive toxicology; dental fluorosis; sperm.