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Brazilian Archives of Biology and Technology
On-line version ISSN 1678-4324
CUSTODIO, Luiz Antonio et al. Detection of Lsr2 gene of Mycobacterium leprae in nasal mucus. Braz. arch. biol. technol. [online]. 2012, vol.55, n.3, pp.375-380. ISSN 1678-4324. http://dx.doi.org/10.1590/S1516-89132012000300007.
In the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.
Keywords : Mycobacterium leprae; leprosy; hanseniase; nasal mucus; PCR.