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Brazilian Archives of Biology and Technology

versão impressa ISSN 1516-8913

Resumo

SILVA, Camila Sloboda Pacheco da et al. Immune response after rabies oral immunization in mice. Braz. arch. biol. technol. [online]. 2013, vol.56, n.6, pp.928-931.  Epub 25-Out-2013. ISSN 1516-8913.  http://dx.doi.org/10.1590/S1516-89132013005000001.

The objective of this study was to formulate an anti-rabies oral vaccine from the cell culture vaccine PV TECPAR to elicit the production of antibodies against the rabies in mice. A vaccine was developed using 107.5 DL50/0.03 ml viral antigens homogenised in lanovaseline to facilitate oral administration. Mice were vaccinated two times for seroconversion. Sera of the vaccinated mice showed a higher level of antibody production than the control group. These results could be used to direct the development of an anti-rabies oral vaccine.

Palavras-chave : Rabies; Oral vaccine; Mice; ELISA.

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