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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


VALADARES, Ydia Mariele et al. In vitro vasodilator activity of Ouratea (Ochnaceae) species and fractions from Ouratea semiserrata (Mart.) engl. Rev. Bras. Cienc. Farm. [online]. 2003, vol.39, n.1, pp.83-91. ISSN 1516-9332.

Ouratea species occur in the cerrado vegetation and some species are popularly used as tonic, astringent and anti-inflammatory. In the present work, we assayed the vasodilator effects of O. castanaefolia, O. spectabilisand O. semiserrata hydroethanolic extracts in aortic rings pre-contracted with phenylephrine. Only O. semiserrata stem extract (OS) produced significant vasodilatation (63 ± 3 %, n = 6), at the concentration of 100 mg/ml. Bioguided fractionation of OS afforded a proanthocyanidin-rich fraction that produced 100 ± 5 % vasodilatation (n = 6; concentration of 100 mg/ml). The total proanthocyanidin contents were assayed for OS and for the bioactive fractions using a spectroscopic method. Higher proanthocyanidin contents implied in increased vasodilator activity (r2 = 0.9760), suggesting that compounds of this class may be regarded as responsible for the activity of O. semiserrata stem extract.

Keywords : Ouratea semiserrata; Ouratea castanaefolia; Ouratea spectabilis; Vasodilator effect; Rat aorta; Total proanthocyanidin content.

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