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Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
OLIVEIRA, Arildo José Braz de and KOIKE, Luzia. An alternative synthesis of 1,2,3,4-tetrahydro-9H-pyrido-[3,4-b]-indole. Rev. Bras. Cienc. Farm. [online]. 2003, vol.39, n.3, pp. 259-264. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322003000300005.
The 1,2,3,4-tetrahydro-9H-pyrido-[3,4-b]-indole, a compound with tranquillizing properties, was prepared in 16% overall yield from the 3-indole-acetaldehyde and tryptamine by applying the classical Pictet-Spengler condensation. Physical and spectroscopic data for such compound are presented.
Keywords : Indole derivatives; Tranquillizing properties; 3-Indoleacetaldehyde; Pictet-Spengler reaction; Oxidation.