Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
CHUNG, Man-Chin et al. Latentiation and advanced drug transport forms. Rev. Bras. Cienc. Farm. [online]. 2005, vol.41, n.2, pp. 155-180. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322005000200004.
This is a review about the molecular modification process, called latentiation, or prodrug design, focusing the progress in the prodrug approach using macromolecules as carriers and drug target systems as: PDEPT ( Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy; GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy and ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-Directed Enzyme-Activated Prodrug Therapy).
Keywords : Latentiation; Prodrug design; Macromolecular carriers; Drug target systems.