SciELO - Scientific Electronic Library Online

 
vol.41 issue2Validation of analytical methods for the determination of active substances in pharmaceutical preparations used in chemical peelingsRanitidine treatment inducing methemoglobinemia in male Wistar rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332

Abstract

RANGEL-YAGUI, Carlota O.; HSU, Helen Wei Ling; PESSOA-JR, Adalberto  and  TAVARES, Leoberto Costa. Micellar solubilization of ibuprofen : influence of surfactant head groups on the extent of solubilization. Rev. Bras. Cienc. Farm. [online]. 2005, vol.41, n.2, pp. 237-246. ISSN 1516-9332.  http://dx.doi.org/10.1590/S1516-93322005000200012.

An important property of micelles with particular significance in pharmacy is their ability to increase the solubility of poorly soluble drugs in water, thus increasing their bioavailability. In this work, the solubilization of ibuprofen (IBU) was studied in micellar solutions of three surfactants possessing the same hydrocarbon tail but different hydrophilic head groups, namely sodium dodecyl sulphate (SDS), dodecyltrimethylammonium bromide (DTAB), and n-dodecyl octa(ethylene oxide) (C12EO8). The results showed that, irrespective of the surfactant type, the solubility of IBU increased linearly with increasing surfactant concentration, as a consequence of the association between the drug and the micelles. The 80 mM DTAB and the 80 mM C12EO8 micellar solutions resulted in a 16-fold increase in solubility of IBU when compared to the buffer solution, whereas the 80 mM SDS micellar solution resulted in a 5.5-fold increase in IBU solubility. The highest value of molar solubilization capacity (c) was obtained with DTAB, c = 0.97, followed by C12EO8 ,c = 0.72, and finally SDS, c = 0.23. However, due to the stronger tendency of the nonionic surfactant in forming micelles in solution, at the same surfactant concentration, we obtained the same solubility of IBU in both DTAB and C12EO8.

Keywords : Micellar solubilization; Surfactant; Ibuprofen.

        · abstract in Portuguese     · text in English     · pdf in English