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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


BOU-CHACRA, Nádia Araci; GOBI, Sandra Sayuri; OHARA, Mitsuko Taba  and  PINTO, Terezinha de Jesus Andreoli. Antimicrobial activity of four different dental gel formulas on cariogenic bacteria evaluated using the linear regression method. Rev. Bras. Cienc. Farm. [online]. 2005, vol.41, n.3, pp.323-331. ISSN 1516-9332.

The antimicrobial activity of four different dental gel formulas was evaluated on three microorganisms associated with cariogenesis: Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. The preliminary antimicrobial activity evaluation was performed using an agar diffusion method. In addition, the formulas were challenged using each microorganism with subsequent determinations of survivors at time intervals of 1, 5, 10, 20 and 30 minutes. The decimal reduction time (D-value) calculated from the obtained curves (logCFU/mL vs. time) was employed for the antimicrobial activity comparison of the formulas. The selected method for survivor enumeration was validated according to official compendia. Results revealed intense bactericidal activity, even at 1:2 dilution, on S. mutans and L. casei. The data concerning A. viscosus showed the absence of microbial reduction in the challenge employing diluted formulas at the selected time interval. The obtained D-values were 0.21, 2.08, 1.93 and 5.79 minutes for formulas 1, 2, 3 and 4, respectively. After comparing the obtained results, formula 1 can be considered to have the highest bactericidal activity.

Keywords : Antimicrobial activity; Dental gel; Linear regression; Validation.

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