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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332

Abstract

YAKABE, Clarice; HONDA, Akimi Mori  and  MAGALHAES, João Fernandes. Determination of 17b-estradiol in dosage formulations: gel and patch. Rev. Bras. Cienc. Farm. [online]. 2005, vol.41, n.3, pp.359-364. ISSN 1516-9332.  http://dx.doi.org/10.1590/S1516-93322005000300009.

A visible spectrophotometry method was developed for quantification of 17b-estradiol in gel and in patch, tranformations by using diazotised sulfanilamide as the colorimetric reagent. The azo-compound formed showed a maximum absorption in 480 nm, and the reaction was linear in a concentration range from 10,0 to 28,0 µg/mL. When applied to dosage formulations it showed to be precise and accurate.

Keywords : 17b-estradiol; Visible spectrophotometry; Gel. Patch. Azo-compound.

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