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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332

Abstract

ZARRANZ, Belén et al. Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives. Rev. Bras. Cienc. Farm. [online]. 2006, vol.42, n.3, pp.357-361. ISSN 1516-9332.  https://doi.org/10.1590/S1516-93322006000300005.

The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

Keywords : Quinoxaline; Antimalarial; Chloroquine; MCF7.

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