Acessibilidade / Reportar erro

Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

Atividade antimalárica de derivados di-N-óxido de 3-trifluorometil-2-carbonilquinoxalina

The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity.

Quinoxaline; Antimalarial; Chloroquine; MCF7


Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo Av. Prof. Lineu Prestes, 950 , Caixa Postal 66083 , 05315-970 - São Paulo - SP - Brasil , Tel.: (011) 3091.3804 , Fax: (011) 3097.8627 - São Paulo - SP - Brazil
E-mail: bjps@usp.br