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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332

Abstract

LOPES, Norberto Peporine; ALMEIDA-PAZ, Filipe Alexandre  and  GATES, Paul Jonathan. Influence of the alkali metal cation on the fragmentation of monensin in ESI-MS/MS. Rev. Bras. Cienc. Farm. [online]. 2006, vol.42, n.3, pp.363-367. ISSN 1516-9332.  http://dx.doi.org/10.1590/S1516-93322006000300006.

The MS/MS fragmentation of the alkali metal complexes of monensin A are studied. The increase in alkali metal ionic radii decreases the ability of the Grob-Wharton fragmentation mechanism to occur and reduces the overall degree of fragmentation. Conversely, the electronegativity of the metal cation is related to the number of fragment ions observed.

Keywords : Polyether ionophore; Monensin; Alkali metal complex; Electrospray tandem mass spectrometry.

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