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Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
HENRIQUES, Bianca Gonzalez; SOUSA, Valéria Pereira de; VOLPATO, Nadia Maria and GARCIA, Sheila. Development and validation of an analytical methodology for determination of glycolic acid acid in raw material and dermocosmetic formulations. Rev. Bras. Cienc. Farm. [online]. 2007, vol.43, n.1, pp.39-45. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322007000100005.
Glycolic acid is widely used in therapeutical care as a soft peeling, leading to the thickness of the horny layer, which is useful in the renewal of the epidermis and the reduction of the face lines. However, in high concentrations it can be associated to a potential of irritation of the skin. A chemical peeling has diverse clinical applications, among them the treatment of injured skin face like: acne, ichthyose, melasma, warts and other else. The present work had the goal to establish and to validate an analytical methodology for the determination of the glycolic acid purity in the raw material and in the dermocosmetic formulations, the acid-base neutralization titration method was used, and the end point was determined with visual indicator as well as potenciometric. The analysis of glycolic acid in the raw material, and particularly, in the finished product is important to maintain the quality control and to guarantee the consumers security. Therefore, the raw material and the products, with glycolic acid, were analyzed in two days, as its purity in free and total glycolic acid was determined using sodium hydroxide 0,1 N and the hydrochloric acid 0,1 N solutions. The developed methodology was based on the reaction with the active substance and with the property characteristics of these formulations. It was demonstrated to be practical and efficient in quantify the glycolic acid.
Keywords : Glycolic acid; Acid-base titration; Potenciometric titration; Quantitative analysis; Validation.