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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


FRANCESCATO, Leandro Nicolodi et al. Antimicrobial activity of Senecio heterotrichius DC.. Rev. Bras. Cienc. Farm. [online]. 2007, vol.43, n.2, pp.239-245. ISSN 1516-9332.

This work describes the evaluation of the antimicrobial activity of CH2Cl2 and EtOH extracts obtained by the maceration of the aerial parts of Senecio heterotrichius DC. against bacterial and fungal pathogens by broth microdilution method. The CH2Cl2 extract showed the best activity against Candida krusei (MIC 0.25 mg/mL) and a moderate activity against Staphyllococcus aureus (MIC 2.5 mg/mL). The EtOH extract was inactive against the tested microorganisms. Besides, one of the main constituents of CH2Cl2 extract was isolated, and its spectroscopic analysis indicated the presence of a sesquiterpene identified as germacrene D.

Keywords : Senecio heterotrichius DC [antimicrobial activity]; Germacrene D; Asteraceae.

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