Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
NERY, Christiane Gino Colu; PIRES, Maria Arlete da Silva; PIANETTI, Gerson Antônio and VIANNA-SOARES, Cristina Duarte. Characterization of the hypoglycemic drug glibenclamide. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.1, pp. 61-73. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322008000100008.
Glibenclamide (GLIB) or glyburide, a second-generation hypoglycemic agent is orally used in the form of tablets for the treatment of diabetes mellitus. Bulk GLIB has a low aqueous solubility and it may yield low drug release in the dissolution test, causing variabilility in the treatment. This work evaluates the bulk GLIB features, which may influence drug release profile, hence, bioavailability, by means of techniques such as nitrogen sorption analysis, laser diffraction, thermal analysis, IV/UV spectroscopy and X-ray analysis.
Keywords : Hypoglycemic agent; Glibenclamide [characterization].