SciELO - Scientific Electronic Library Online

vol.44 issue3Overcoming hurdles through innovation, persistence and creativeness in the development of probiotic foodsMolecular Imprinting: a promising strategy in matrices elaboration for drug delivery systems author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


SANTOS, Cledir. Intramolecular cyclization: a promising strategy in the prodrug conception. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.3, pp.349-360. ISSN 1516-9332.

Many drugs used for the treatment of common diseases are associated with various adverse effects and limited bioavailability. The suppression of such problems continues to be a very important target for scientists. The development of prodrugs for controlled release in vivo is an attractive way to overcome these problems. Classical in prodrug is an inactive molecule which the parent drug is covalently bonded to a carrier unit, and which can liberate the drug through chemical or enzymatic pathways. A new and interesting prodrug system for amine, alcohol, and thiol drugs takes advantage of several easy intramolecular cyclization reactions. So, the cyclization process can control the release rate of the parent drug. In this paper is a review about the prodrug strategies based on intramolecular cyclization reactions is presented.

Keywords : Prodrugs; Intramolecular cyclization; Drugs [controlled release].

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License