Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
FERREIRA, Alexandre; MAROCO, Elisangela; YONAMINE, Mauricio and OLIVEIRA, Magda Lúcia Félix de. Organophosphate and carbamate poisonings in the northwest of Paraná state, Brazil from 1994 to 2005: clinical and epidemiological aspects. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.3, pp. 407-415. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322008000300010.
In the present study, clinical and epidemiological aspects of 529 intoxication cases of organophosphate or carbamate pesticides in the northwest of the state of Paraná, Brazil, over a twelve-year period (1994-2005), are presented. One hundred-five of 257 patients (40.8%) who attempted suicide were admitted to Intensive Care Units (ICUs), with an average hospital stay of two days (range 1-40 days). Men corresponded to 56.4% of the cases of suicide attempts and sixteen individuals died. One hundred-forty patients intoxicated due to occupational exposure were all young adults and nine of them were admitted to ICU, with average hospital stays of eight days (range 1-16 days). Of these cases, two patients died. One hundred twenty-four patients intoxicated due to accidental exposure were mainly children and had a hospital average stay of four days. Twenty patients were admitted to the ICU, and one of them died. Overall complications included respiratory failure, convulsions, and aspiration pneumonia. Deliberate ingestion of organophosphates and carbamates was much more toxic than occupational and accidental exposure. Men aged 15-39 years were the most likely to attempt suicide with these agents and had more prolonged ICU with significant complications and mortality.
Keywords : Organophosphate pesticides [toxicity]; Carbamate [toxicity]; Anticholinesterase pesticides [occupational exposure]; Acute intoxication.