SciELO - Scientific Electronic Library Online

vol.44 issue3The presence of pharmaceutical excipients as possible cause of adverse drug reactions (ADR) - situation in BrazilRepeated administration of caffeine increases femproporex-induced locomotor activity in adolescent and adult rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


FERREIRA, Alexandre; MAROCO, Elisangela; YONAMINE, Mauricio  and  OLIVEIRA, Magda Lúcia Félix de. Organophosphate and carbamate poisonings in the northwest of Paraná state, Brazil from 1994 to 2005: clinical and epidemiological aspects. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.3, pp.407-415. ISSN 1516-9332.

In the present study, clinical and epidemiological aspects of 529 intoxication cases of organophosphate or carbamate pesticides in the northwest of the state of Paraná, Brazil, over a twelve-year period (1994-2005), are presented. One hundred-five of 257 patients (40.8%) who attempted suicide were admitted to Intensive Care Units (ICUs), with an average hospital stay of two days (range 1-40 days). Men corresponded to 56.4% of the cases of suicide attempts and sixteen individuals died. One hundred-forty patients intoxicated due to occupational exposure were all young adults and nine of them were admitted to ICU, with average hospital stays of eight days (range 1-16 days). Of these cases, two patients died. One hundred twenty-four patients intoxicated due to accidental exposure were mainly children and had a hospital average stay of four days. Twenty patients were admitted to the ICU, and one of them died. Overall complications included respiratory failure, convulsions, and aspiration pneumonia. Deliberate ingestion of organophosphates and carbamates was much more toxic than occupational and accidental exposure. Men aged 15-39 years were the most likely to attempt suicide with these agents and had more prolonged ICU with significant complications and mortality.

Keywords : Organophosphate pesticides [toxicity]; Carbamate [toxicity]; Anticholinesterase pesticides [occupational exposure]; Acute intoxication.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License