SciELO - Scientific Electronic Library Online

vol.44 issue3Design and release characteristics of sustained release tablet containing metformin HClCapacity of the extracellular matrix of the bone marrow to induce proliferation of myeloid cells in vitro in model of protein malnutrition in mice author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


OLIVEIRA, Rodrigo Borges de et al. Evaluation of the central depressor effects of the ethanolic extract of the leaves of Synadenium umbellatum Pax. and its fractions in Swiss mice. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.3, pp.485-491. ISSN 1516-9332.

Synadenium umbellatum Pax. (Euphorbiacea) is a native plant from tropical Africa known as "cola-nota", "avelós", "cancerola", "milagrosa", among others. The plant is used by Brazilian folks for having anti-inflammatory and analgesic properties, among others. It was evaluated the depressor effects over the central nervous system (CNS) of the ethanolic extract of the leaves of Synadenium umbellatum (EES) and its fractions - hexane (HF), chloroformic (CF) and methanol/water fractions(MF). Several tests were used in Swiss mice (Mus musculus), among them, barbiturate-induced sleep, open field and rota-rod test. The EES was tested at 25, 50 and 100 mg/kg doses, while the HF was tested at 10 mg/kg dose, the CF at 20 mg/kg dose and the MF at 25 mg/kg dose. The EES and the HF and the CF fractions, but not the MF, have presented a possible depressor effect over the CNS once they were able to increase the stop time and decrease the number of fecal boli on the open field, besides they were able to potencialize the barbiturate-induced sleep. The rota-rod test showed that the EES and the fractions were not able to cause motor incoordination or muscle relax. Therefore, we conclude that Synadenium umbellatum Pax. have a possible depressor effect over the CNS.

Keywords : Ethanolic extract; Synadenium umbellatum; Central nervous system.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License