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Revista Brasileira de Ciências Farmacêuticas

versão impressa ISSN 1516-9332

Resumo

RAMOS, Daniela Fernandes et al. Investigation of the antimycobacterial activity of 36 plant extracts from the brazilian Atlantic Forest. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.4, pp. 669-674. ISSN 1516-9332.  http://dx.doi.org/10.1590/S1516-93322008000400013.

Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.

Palavras-chave : Mycobacterium tuberculosis; Mycobacterium kansasii; Plant extracts [antimycobacterial activity]; Antimycobacterials; Cytotoxicity.

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