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Revista Brasileira de Ciências Farmacêuticas
Print version ISSN 1516-9332
BROINIZI, Priscila Regina Bolelli et al. Antioxidant properties in cashew apple byproduct (Anacardium occidentale L.): effect on lipoperoxidation and on the polyunsaturated fatty acids profile in rats. Rev. Bras. Cienc. Farm. [online]. 2008, vol.44, n.4, pp.773-781. ISSN 1516-9332. http://dx.doi.org/10.1590/S1516-93322008000400025.
The cashew apple (Anacardium occidentale L.) contains phenolic compounds usually related with antioxidant properties. Then, the aim of this study was to investigate its antioxidant capacity. The antioxidant capacity of the hydroalcoholic extract of the cashew apple pulp (EHAlc.) was assessed for the scavenging of the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) by in vitro method and by an in vivo essay. For this essay a 30-day oral (gavage, EHAlc. 200 and 400 mg/kg) study was conducted in Wistar male rats, evaluating hepatic, plasma and brain tissues. In DPPH model, the extract demonstrated antioxidant activity of 95 % (largest concentration, 1000 µg/ mL). There were found no relevant peroxidation comparing the treated animals with the control group. However, the treated group presented a lower level of brain lipoperoxidation. Also in the treated animals brain tissue was found the largest amount of polyunsaturated fatty acids (PUFA), mainly docosahexaenoic (DHA). Therefore, the analyzed extract from cashew apple pulp clone CCP-76 contains effective natural antioxidants, responsible for free radical scavenging in vitro and also for decreasing the brain lipoperoxidation and keeping the PUFAS levels in Wistar rats.
Keywords : Cashew apple [propeties]; Lipoperoxidation; Fatty acids [polyunsaturated]; Fatty acids [experimental study]; Docosahexaenoic acid; Natural antioxidants.