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Pesquisa Odontológica Brasileira

Print version ISSN 1517-7491


MIYAJI, Cintia Kaori  and  COLUS, Ilce Mara de Syllos. Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation. Pesqui. Odontol. Bras. [online]. 2002, vol.16, n.3, pp.196-201. ISSN 1517-7491.

Exposure to X-rays (ionizing radiation) may cause chromosomal aberrations (CA) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. This study was carried out to assess the CA frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in Londrina, Paraná, Brazil, who have worked for more than ten years with X-rays. The results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to X-rays. All individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. Slides, prepared after the cultures, were stained with Giemsa, and 100 to 200 metaphase cells were analyzed per individual. CA frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. The analysis of mitotic index (MI) did not indicate significant differences (p < 0.05) between the group of individuals exposed to X-rays and the control group. The analyzed confounding factors did not influence the results of MI and CA frequencies.

Keywords : Chromosome aberrations; Occupational exposure; Mitotic index; Dentist's practice patterns; X-rays.

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