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Pesquisa Odontológica Brasileira

Print version ISSN 1517-7491

Abstract

BOSCO, Vera Lúcia; BIRMAN, Esther Goldenberg; CURY, Arlete Emily  and  PAULA, Claudete Rodrigues. Yeasts from the oral cavity of children with AIDS: exoenzyme production and antifungal resistance. Pesqui. Odontol. Bras. [online]. 2003, vol.17, n.3, pp.217-222. ISSN 1517-7491.  http://dx.doi.org/10.1590/S1517-74912003000300004.

The oral fungal microbiota of 30 children with AIDS, of both genders, aged from two to six years, receiving outpatient treatment, was evaluated and compared with that of a control group composed of 30 healthy subjects with matching ages and genders. Virulence factors, such as exoenzyme production, and susceptibility to five antifungal agents using an E-Test kit were evaluated. C. albicans predominated over other species in the AIDS group, showing a higher production of proteinase and phospholipase when compared with that observed in the control group. In this study few clinical manifestations of and low selectivity for C. albicans (23.3%) were observed in the AIDS group. The enzymatic studies showed that 53.8% of the AIDS strains were strongly positive whereas only 33.3% of the non-AIDS strains were positive. Amphotericin B was the most effective drug among the antifungal agents tested against C. albicans. The frequency, selectivity and level of exoenzyme production by C. albicans suggest a higher pathogenicity in the AIDS children than in the control children.

Keywords : Acquired immunodeficiency syndrome; Child; Antifungal agents.

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