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Brazilian Journal of Microbiology
On-line version ISSN 1678-4405
ANJOS FILHO, Luciano dos et al. Sensitivity of AMPLICOR MTB on direct detection of Mycobacterium tuberculosis in smear-negative specimens from outpatients in Rio de Janeiro. Braz. J. Microbiol. [online]. 2002, vol.33, n.2, pp. 163-165. ISSN 1678-4405. http://dx.doi.org/10.1590/S1517-83822002000200013.
We evaluated the performance of the AMPLICOR MTB assay for detection of M. tuberculosis in clinical specimens obtained from 98 smear-negative tuberculous patients (43 with positive and 55 with negative culture results). The sensitivity of the AMPLICOR MTB was 44.9% (44/98) and that of culture was 43.8% (43/98). No significant difference was observed between the results obtained by AMPLICOR MTB and by culture. We conclude that amplification assays could be used for testing smear-negative specimens because a rapid diagnosis will benefit those patients.
Keywords : tuberculosis; AMPLICOR MTB; smear-negative specimens.