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Brazilian Journal of Microbiology

versão impressa ISSN 1517-8382versão On-line ISSN 1678-4405

Resumo

FERNANDES, Maria Judite B. et al. Cytotoxicity of subfractions and compounds from Polymnia sonchifolia. Braz. J. Microbiol. [online]. 2005, vol.36, n.4, pp.338-341. ISSN 1517-8382.  http://dx.doi.org/10.1590/S1517-83822005000400006.

Our previous works showed that extracts and fractions from Polymnia sonchifolia had presented an inhibitory activity on growth and aflatoxin production by Aspergillus flavus in non-cytotoxic concentrations. In this work, report results on the in vitro cytotoxicity of subfractions and of a mixture of sesquiterpenes lactones from Polymnia sonchifolia on Vero cells. The cytotoxicity was assayed through crystal violet staining (CVS) method and the 50% inhibitory concentration for cell growth (IC50) was calculated. Both subfractions and the mixture of sesquiterpenes lactones did not show in vitro cytotoxicity to Vero cells on active biologically concentrations against production of aflatoxin B1 by Aspergillus flavus.

Palavras-chave : Polymnia sonchifolia; subfractions; lactones; cytotoxicity; crystal violet staining (CVS) method.

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