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Brazilian Journal of Microbiology
On-line version ISSN 1678-4405
ZHANG, Jing et al. Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen. Braz. J. Microbiol. [online]. 2009, vol.40, n.4, pp.965-971. ISSN 1678-4405. http://dx.doi.org/10.1590/S1517-83822009000400031.
This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients.
Keywords : Hepatitis B virus; precore mutation; pre-S1.