Brazilian Journal of Microbiology
versión impresa ISSN 1517-8382
LEMES, Raquel M.L.; LYON, Juliana P.; MOREIRA, Leonardo M. y RESENDE, Maria Aparecida de. Antifungal susceptibility profile of Trichosporon isolates: correlation between CLSI and etest methodologies. Braz. J. Microbiol. [online]. 2010, vol.41, n.2, pp. 310-315. ISSN 1517-8382. http://dx.doi.org/10.1590/S1517-83822010000200008.
The aim of the present study was to evaluate the antifungal susceptibility profile of Trichosporon species isolated from different sources employing the Clinical and Laboratory Standards Institute (CLSI) method and E-test method. Thirty-four isolates of Trichosporon spp. and six CBS reference samples were tested for their susceptibility to Amphotericin B, 5-flucytosine, Fluconazole, Itraconazole, Voriconazole and Terbinafine. All species showed high Minimun Inhibitory Concentrations (MIC) for Itraconazole and susceptibility to Fluconazole, The comparison among the results obtained by the CLSI method and E-test revealed larger discrepancies among 5-flucytosine and Itraconazole. The present work provides epidemiological data that could influence therapeutic choices. Furthermore, the comparison between different methodologies could help to analyze results obtained by different laboratories.
Palabras llave : Trichosporon spp; antifungal drugs; CLSI; E-test.