SciELO - Scientific Electronic Library Online

vol.41 issue4The role of mycorrhization helper bacteria in the establishment and action of ectomycorrhizae associationsApplication of microbial α-amylase in industry - A review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Journal of Microbiology

Print version ISSN 1517-8382


LYON, Juliana P. et al. Candida albicans: genotyping methods and clade related phenotypic characteristics. Braz. J. Microbiol. [online]. 2010, vol.41, n.4, pp.841-849. ISSN 1517-8382.

Several molecular methods, such as Southern blotting hybridization, Multilocus Sequence Typing, and DNA microsatellite analysis, have been employed to genotype Candida albicans. The genotype analysis allows to group strains in clades, that is, a group composed of one ancestor and its descendants. These genotype studies demonstrate that clades distribution is influenced by geographic area as well as that antifungal resistance is associated with particular clades. These findings suggested that C. albicans reproduces mainly in a clonal manner, with certain degree of DNA microevolution. Additionally, virulence factors and site of isolation have also been associated with clade specificity. The present article is a brief review about the methods used for Candida genotyping and the correlated clade systems established. Special emphasis is given to Ca3 hybridization, MLST, and Microsatellites. The present work is also focused on the phenotypic and physiological traits associated with Candida clades.

Keywords : Candida albicans; clonal reproduction; microevolution; genotyping systems; phenotypic characteristics.

        · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License