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Brazilian Journal of Microbiology

Print version ISSN 1517-8382

Abstract

MATOS, Denise Cristina Souza et al. Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine. Braz. J. Microbiol. [online]. 2012, vol.43, n.2, pp. 429-431. ISSN 1517-8382.  http://dx.doi.org/10.1590/S1517-83822012000200001.

The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.

Keywords : DTP vaccine; Pertussis whole cell; enzyme-linked immunosorbent assay; intracerebral mouse protection test.

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