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Brazilian Journal of Microbiology

versão impressa ISSN 1517-8382versão On-line ISSN 1678-4405

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THIPPESWAMY, Sreerangegowda; MOHANA, Devihalli Chikkaiah; ABHISHEK, Rayasandra Umesh  e  MANJUNATH, Kiragandur. Evaluation of some pharmacological activities of Budmunchiamine - A isolated from Albizia amara. Braz. J. Microbiol. [online]. 2015, vol.46, n.1, pp.139-143. ISSN 1517-8382.  http://dx.doi.org/10.1590/S1517-838246120131137.

The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara. The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara. The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50% (IC50) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8%. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry.

Palavras-chave : Albizia amara; budmunchiamine-A; antimicrobial activity; antioxidant activity.

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