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Brazilian Journal of Microbiology

Print version ISSN 1517-8382On-line version ISSN 1678-4405

Abstract

CALDAS, Lúcio Ayres; FREITAS, Tânia Rosária Pereira; AZEVEDO, Renata Campos  and  DE SOUZA, Wanderley. Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus. Braz. J. Microbiol. [online]. 2018, vol.49, n.4, pp.785-789. ISSN 1517-8382.  http://dx.doi.org/10.1016/j.bjm.2017.12.010.

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).

Keywords : Bovine viral diarrhea virus; BVDV; Prostaglandins; Prostaglandin A1; Virus-induced vacuolization.

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