SciELO - Scientific Electronic Library Online

 
vol.18 número3Análise da correlação entre o protocolo Polar Fitness Test® para predição de VO2máx e ergoespirometriaInfluência do nível de desempenho de jogadores de badminton em aspectos neuromotores durante uma tarefa de apontar um alvo índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Revista Brasileira de Medicina do Esporte

versão impressa ISSN 1517-8692

Resumo

ACCIOLY, Marilita Falângola et al. Effect of physical exercise and statins on the muscle function in animals with dyslipidemia. Rev Bras Med Esporte [online]. 2012, vol.18, n.3, pp. 198-202. ISSN 1517-8692.  http://dx.doi.org/10.1590/S1517-86922012000300013.

Statins are used in the treatment of dyslipidemias with great tolerance; however, several side effects can arise, mainly myopathies. Regular practice of physical exercises (PE) produces beneficial alteration in the lipid profile, but it can result in muscular lesions. OBJECTIVE: to evaluate the effect of the association between physical exercise and statins in the muscular function through histological analysis in an experimental animal model with dyslipidemia. METHODS: 80 male Wistar mice, distributed in 8 groups, namely: animals submitted to a hypercholesterolemic diet (HD), symvastatin with (G1) and without PE (G2) ; HD and fluvastatin with (G3) and without PE (G4); fed with commercial food (CR) in the presence (G5) and absence of PE (G6);  HD submitted (G7) or not (G8) to PE were used. The HD was administered statins and PE practice on treadmill for 90 days for 8 weeks. The animals were sacrificed, and the soleus muscle was removed for histological analysis. Paired t-tests and multivariate analysis were applied with significance level of p<0.05. RESULTS: The most important histological alterations found were fibers with different diameters and atrophic, with degeneration, splitting, edema and inflammatory infiltrate. These alterations were observed in 90% of animals from G1; 80% from G2; 70% from G3; 30% from G4; 40% from G5 and 30% from G7. In the G6 and G8 groups muscular fibers with preserved morphology were identified. CONCLUSION: In the muscular histological evaluation, the association of fluvastatin, symvastatin and physical exercise results in morphological alterations with predominance with the use of simvastatin, varying from a light to a high level, in the soleus muscle of mice, induced by HMG-CoA reductase inhibitors.

Palavras-chave : HMG-CoA reductase inhibitors; aerobic physical exercise; myopathy.

        · resumo em Português     · texto em Português | Inglês     · pdf em Português | Inglês