Revista Brasileira de Saúde Materno Infantil
On-line version ISSN 1806-9304
ARRUDA, José Germano Ferraz de; MARTINS, Alex Tadeu and AZOUBEL, Reinaldo. Sodium cyclamate and fetal kidney. Rev. Bras. Saude Mater. Infant. [online]. 2003, vol.3, n.2, pp.147-150. ISSN 1806-9304. http://dx.doi.org/10.1590/S1519-38292003000200003.
Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It is present in the formula of products such as sodium and calcium cyclamates and cyclamic acid. Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus. It has been demonstrated in rats that the kidney may be adversely affected by high doses of cyclamate. Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.
Keywords : Sodium cyclamate; Kidney; Fetal health.