Raza et al. (2004)Raza, H., Ahmed, I. and John, A., 2004. Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: modulation by extract. Momordica charantia (karela)Life Sciences, vol. 74, no. 12, pp. 1503-1511. http://dx.doi.org/10.1016/j.lfs.2003.08.023. PMid:14729399. http://dx.doi.org/10.1016/j.lfs.2003.08....
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Streptozotocin |
Momordica charantia
|
One healthy and one diabetic experimental group received orally the extract of seeds of Momordica charantia at the dose of 10 ml/kg daily for 14 days |
Endogenous peroxidase activity, localization of GST alpha |
Mallick et al. (2007)Mallick, C., Mandal, S., Barik, B., Bhattacharya, A. and Ghosh, D., 2007. Protection of testicular dysfunctions by MTEC, a formulated herbal drug, in streptozotocin induced diabetic rat. Biological & Pharmaceutical Bulletin, vol. 30, no. 1, pp. 84-90. http://dx.doi.org/10.1248/bpb.30.84. PMid:17202665. http://dx.doi.org/10.1248/bpb.30.84...
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Streptozotocin |
Musa paradisiaca, Tamarindus indica, Eugenia jambolana and Coccinia indica
|
One diabetic experimental group was orally treated with a compound of specific parts of the species Musa paradisiaca, Tamarindus indica, Eugenia jambolana Coccinia indica at the dose of 60 mg/0.5 ml olive oil/100 g body weight/twice daily for 14 days |
Gonadosomatic index, serum testosterone, sperm count and viability, testicular glucose level, activities of testicular catalase and glutathione peroxidase, lipid peroxidation, quantification of germ cells at stage VII in seminiferous epithelial cycle, seminiferous tubules diameter, Leydig cell nuclear area |
Hamden et al. (2008)Hamden, K., Carreau, S., Jamoussi, K., Ayadi, F., Garmazi, F., Mezgenni, N. and Elfeki, A., 2008. Inhibitory effects of 1alpha, 25dihydroxyvitamin D3 and . Ajuga iva extract on oxidative stress, toxicity and hypofertility in diabetic rat testesJournal of Physiology and Biochemistry, vol. 64, no. 3, pp. 231-239. http://dx.doi.org/10.1007/BF03216108. PMid:19244937. http://dx.doi.org/10.1007/BF03216108...
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Alloxan |
Ajuga iva
|
One diabetic experimental group received orally the aqueous extract of Ajuga iva at the dose of 50 mg/kg for three weeks. Another experimental group received the same extract in the same concentration for three weeks before diabetes induction |
Sperm count and motility, 17-β estradiol levels, serum testosterone, lipid peroxidation, antioxidant enzymes activity, total protein |
Azeez et al. (2010)Azeez, O.I., Oyagbemi, A.A., Oyeyemi, M.O. and Odetola, A.A., 2010. Ameliorative effects of on alloxan toxicity in Wistar rats. Cnidoscolus aconitifoliusAfrican Health Sciences, vol. 10, no. 3, pp. 283-291. PMid:21327141.
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Alloxan |
Cnidoscolus aconitifolius
|
Three diabetics experimental groups received orally doses of ethanol extract of Cnidoscolus aconitifolius in different concentrations (100 mg/kg, 500 mg/kg and 1000 mg/kg) daily for 28 days |
Motility, number, morphology and viability of sperm |
Mallick et al. (2010)Mallick, C., Bera, T.K., Ali, K.M., Chatterjee, K. and Ghosh, D., 2010. Diabetes-induced testicular disorders vis-a-vis germ cell apoptosis in albino rat: Remedial effect of hexane fraction of root of and leaf of Musa paradisiacaCoccinia indica.Journal of Health Science, vol. 56, no. 6, pp. 641-654. http://dx.doi.org/10.1248/jhs.56.641. http://dx.doi.org/10.1248/jhs.56.641...
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Streptozotocin |
Musa paradisiaca and Coccinia indica
|
One diabetic experimental group was orally treated with hexane fraction of hydro-methanolic extract of root of Musa paradisiaca and leaf of Coccinia indica at the dose of 2 mg/0.2 ml olive oil/100 g body weight for 45 days |
Serum testosterone, sperm count and viability, antioxidant enzymes activity, lipid peroxidation, incidence of apoptosis in seminiferous tubules, quantification of germ cells at stage VII in seminiferous epithelial cycle and giant cell in testicular section |
Shahreari et al. (2010)Shahreari, S., Khaki, A., Ahmadi-Ashtiani, H.R., Rezazadeh, S. and Hajiaghaei, R., 2010. Effects of Danae racemosa on testosterone hormone in experimental diabetic rats. Journal of Medicinal Plants, vol. 9, no. 35, pp. 114-119.
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Streptozotocin |
Danae racemosa
|
One healthy and one diabetic experimental group were orally treated with the extract of Danae racemosa at the dose of 400 mg/kg daily for four weeks |
Serum testosterone |
Golalipour et al. (2011)Golalipour, M.J., Kabiri Balajadeh, B., Ghafari, S., Azarhosh, R. and Khori, V., 2011. Protective effect of Urtica dioica L. (Urticaceae) on morphometric and morphologic alterations of seminiferous tubules in STZ diabetic rats. Iranian Journal of Basic Medical Sciences., vol. 14, no. 5, pp. 472-477. PMid:23493848.
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Streptozotocin |
Urtica dioica
|
One experimental group received an intraperitoneal injection with extract of Urtica dioica leaves at a dose of 100 mg/kg for 5 days. On the sixth day, the animals were induced to experimental diabetes |
Seminiferous tubules diameter, seminiferous epithelial height |
Chatterjee et al. (2012)Chatterjee, K., Ali, K.M., De, D., Bera, T.K., Jana, K., Maiti, S., Ghosh, A., Samanta, R. and Ghosh, D., 2012. Diabetes induced testicular dysfunction amelioration by ethyl acetate fraction of hydromethanolic extract of root of L. in streptozotocin induced diabetic rat. Musa paradisiacaAsian Pacific Journal of Tropical Disease, vol. 2, no. 1, pp. 233-241. http://dx.doi.org/10.1016/S2222-1808(12)60158-3. http://dx.doi.org/10.1016/S2222-1808(12)...
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Streptozotocin |
Musa paradisiaca
|
One diabetic experimental group was orally treated with ethyl acetate fraction of hydromethanolic extract of root of Musa paradisiaca at the dose of 20 mg/0.5 ml distilled water/100 g body weight |
Antioxidant enzymes activity, lipid peroxidation, testicular cholesterol level, sperm count and motility, testicular Bax-α mRNA expression pattern, seminiferous tubules diameter and testicular histology |
Suresh et al. (2013)Suresh, S., Prithiviraj, E., Lakshmi, N.V., Ganesh, M.K., Ganesh, L. and Prakash, S., 2013. Effect of . Mucuna pruriens (Linn.) on mitochondrial dysfunction and DNA damage in epididymal sperm of streptozotocin induced diabetic ratJournal of Ethnopharmacology, vol. 145, no. 1, pp. 32-41. http://dx.doi.org/10.1016/j.jep.2012.10.030. PMid:23103904. http://dx.doi.org/10.1016/j.jep.2012.10....
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Streptozotocin |
Mucuna pruriens
|
One healthy and one diabetic experimental group received orally the ethanolic extract of seeds of Mucuna pruriens at the dose of 200 mg/kg once a day for 60 days |
Sperm count, morphology, motility, DNA integrity, quantitative assessment of DNA damage, estimation of lipid peroxidation and antioxidant |
Chatterjee et al. (2013)Chatterjee, K., Ali, K.M., De, D., Bera, T.K., Jana, K., Maiti, S., Ghosh, A. and Ghosh, D., 2013. Hyperglycemia-induced alteration in reproductive profile and its amelioration by the polyherbal formulation MTEC (modified) in streptozotocininduced diabetic albino rats. Biomarkers and Genomic Medicine, vol. 5, no. 1-2, pp. 54-66. http://dx.doi.org/10.1016/j.gmbhs.2013.04.007. http://dx.doi.org/10.1016/j.gmbhs.2013.0...
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Streptozotocin |
Musa paradisiaca, Tamarindus indica, Eugenia jambolana and Coccinia indica
|
One diabetic experimental group was orally treated with a compound of specific parts of solvent fractions of Musa paradisiaca, Tamarindus indica, Eugenia jambolana and Coccinia indica at the dose of 10 mg/0.5 ml of 2% Tween 80/100 g body weight twice daily for 28 days |
Gonadosomatic index, sperm count and motility, seminal vesicular fructose and testicular cholesterol levels, serum testosterone, antioxidant enzymes activity, estimation of lipid peroxidation, Bax-α protein expression, histological evaluation of the testis |
Michael et al. (2013)Michael, H.N., Salib, J.Y. and Eskander, E.F., 2013. Bioactivity of diosmetin glycosides isolated from the epicarp of date fruits, , on the biochemical profile of alloxan diabetic male rats. Phoenix dactyliferaPhytotherapy Research, vol. 27, no. 5, pp. 699-704. http://dx.doi.org/10.1002/ptr.4777. PMid:22761049. http://dx.doi.org/10.1002/ptr.4777...
|
Alloxan |
Phoenix dactylifera
|
Two diabetic experimental groups were orally treated with solutions of the component 1 (diosmetin 7-O-β-L-arabinofuranosyl (1→2) β-D-apiofuranoside) and component 2 (diosmetin 7-O-β-D-apiofuranoside) isolated from the acetone extract of Phoenix dactylifera
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Serum testosterone |
Salib et al. (2013)Salib, J.Y., Michael, H.N. and Eskande, E.F., 2013. Antidiabetic propertiers of flavonoid compounds isolated from epicarpo on alloxan induced diabetic rats. Hyphaene thebaicaPharmacognosy Research, vol. 5, no. 1, pp. 22-29. http://dx.doi.org/10.4103/0974-8490.105644. PMid:23598921. http://dx.doi.org/10.4103/0974-8490.1056...
|
Alloxan |
Hyphaene thebaica
|
One diabetic experimental group received orally an aqueous solution of the soluble fraction of Hyphaene thebaica (20 mg/kg) daily for 30 days. A second diabetic group received orally a component 5 solution of soluble aqueous fraction of Hyphaene thebaica (20 mg/kg) daily for 30 days |
Serum testosterone |
Singh et al. (2013)Singh, R., Bhardwaj, P. and Sharma, P., 2013. Antioxidant and toxicological evaluation of streptozotocin-induced diabetic Wistar rats. Cassia sopherainPharmacognosy Research, vol. 5, no. 4, pp. 225-232. http://dx.doi.org/10.4103/0974-8490.118767. PMid:24174814. http://dx.doi.org/10.4103/0974-8490.1187...
|
Streptozotocin |
Cassia sophera
|
One diabetic experimental group was orally treated with the aqueous extract of Cassia sophera (200 mg/kg) for 28 days |
Lipid peroxidation, concentration of enzymatic and non-enzymatic antioxidants and protein concentration |
Ukwenya et al. (2013)UKWENYA, V., ASHAOLU, O., ADEYEMI, D., OBUOTOR, E., TIJANI, A., BILIAMINU, A. and CAXTON-MARTINS, E., 2013. Evaluation of antioxidant potential of methanolic leaf extract of Anacardium occidentale on the testes of streptozotocin induced diabetic wistar rats. European Journal of Anatomy, vol. 2, no. 17, pp. 72-81.
|
Streptozotocin |
Anacardium occidentale
|
One diabetic experimental group received orally 300 mg/kg of the methanol extract of Anacardium occidentale sheet daily for 16 days |
Lipid peroxidation, antioxidant enzymes activity, histological evaluation of the testis |
Wankeu-Nya et al. (2013)Wankeu-Nya, M., Florea, A., Bâlici, S., Watcho, P., Matei, H. and Kamanyi, A., 2013. alleviates ultra-structural spermatogenesis alterations in streptozotocin induced diabetic rats. Dracaena arboreaBMC Complementary and Alternative Medicine, vol. 13, pp. 71. PMid:23548080.
|
Streptozotocin |
Dracaena arborea
|
Two diabetic experimental group were orally treated with the aqueous extract and the ethanol extract of Dracaena arborea at a dose of 100 mg/kg and 500 mg/kg daily for 3 weeks |
Testicular morphology |
Ghosh et al. (2014)Ghosh, A., Jana, K., Ali, K.M., De, D., Chatterjee, K. and Ghosh, D., 2014. Corrective role of Eugenia jambolana on testicular impairment in streptozotocin-induced diabetic male albino rat: An approach through genomic and proteomic study. Andrologia, vol. 46, no. 3, pp. 296-307. http://dx.doi.org/10.1111/and.12081. http://dx.doi.org/10.1111/and.12081...
|
Streptozotocin |
Eugenia jambolana
|
One diabetic experimental group was orally treated with the ethyl acetate fraction of the hydromethanolic extract of Eugenia jambolana at a dose of 20 mg/0.5 ml of distilled water/100 g body weight for 60 days |
Gonadosomatic index, seminiferous tubules diameter, sperm count, seminal vesicular fructose level, quantification of germ cells at stage VII in seminiferous epithelial cycle, antioxidant enzymes activity, serum testosterone, analysis of Bax and Bcl-2 gene expression |
Giribabu et al. (2014)Giribabu, N., Kumar, K.E., Rekha, S.S., Muniandy, S. and Salleh, N., 2014. (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin induced adult male diabetic rats. Chlorophytum boviriliarumBMC Complementary and Alternative Medicine, vol. 14, no. 291, pp. 377. PMid:25283233.
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Streptozotocin |
Chlorophytum borivilianum
|
Two experimental diabetic group orally treated with aqueous Chlorophytum borivilianum extract at a dose of 250 mg/kg and 500 mg/kg for 28 days |
Sperm count, morphology, motility and viability, sperm’s flagella membrane integrity, lipid peroxidation, hydrogen peroxide and nitric oxide levels, sperm total antioxidant capacity, activity levels of endogenous antioxidant enzymes, expression of sperm caspase-3 |
Hajizadeh et al. (2014)Hajizadeh, M., Eftekhar, E., Zal, F., Jafarian, A. and Mostafavi-Pour, Z., 2014. Mulberry leaf extract attenuates oxidative stress mediated testosterone depletion in streptozotocin induced diabetic rats. Iranian Journal of Medical Sciences, vol. 39, no. 2, pp. 123-129. PMid:24644381.
|
Streptozotocin |
Morus alba
|
One diabetic experimental group received orally Morus alba extract at a dose of 1 g/kg per day for 8 weeks |
Lipid peroxidation, antioxidant enzymes activity, mRNA expression level of StAR and P450scc |
Shah and Khan (2014)Shah, N.A. and Khan, M.R., 2014. Antidiabetic effect of in alloxan induced diabetic rats. Sida cordataBioMed Research International, vol. 2014, pp. 671294. http://dx.doi.org/10.1155/2014/671294. PMid:25114914. http://dx.doi.org/10.1155/2014/671294...
|
Alloxan |
Sida cordata
|
Two experimental diabetic groups received orally the ethyl acetate fraction of Sida cordata at a dose of 150 mg/kg and 300 mg/kg for 15 days |
Lipid peroxidation, hydrogen peroxide, nitrite and protein levels |