SciELO - Scientific Electronic Library Online

 
vol.77 número2Conteúdo nutricional de frutos consumidos por morcegos em um fragmento florestal do sul do BrasilRespostas de crescimento e acúmulo de açúcares solúveis em Inga marginata Willd. (Fabaceae) submetida ao alagamento e sob condições contrastantes de luminosidade índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Brazilian Journal of Biology

versão impressa ISSN 1519-6984versão On-line ISSN 1678-4375

Resumo

OLIVEIRA, J. B.; EVENCIO-NETO, J.  e  BARATELLA-EVENCIO, L.. Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review. Braz. J. Biol. [online]. 2017, vol.77, n.2, pp.251-259.  Epub 05-Set-2016. ISSN 1519-6984.  http://dx.doi.org/10.1590/1519-6984.11115.

The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS). Inclusion and exclusion criteria for articles were established, and a total number of 14 articles were selected and used. There are few publications that clarify how the salivary gland acini behave with application of botulinum toxin. Although, the immunohistochemical findings were consistent among authors, showing weak immunoreactivity in glands treated with botulinum toxin. Histometric data are divergent, requiring more detailed studies to answer the questions about the efficacy and safety of botulinum toxin in salivary glands.

Palavras-chave : botulinum toxins; salivary glands; sialorrhea; botulinum toxin type A.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )