Jornal Brasileiro de Patologia e Medicina Laboratorial
On-line version ISSN 1678-4774
PRIOSTE, Rogério Nogueira et al. Homocystein metabolism alterations induced by sugar-cane liquor in alcoholics. J. Bras. Patol. Med. Lab. [online]. 2003, vol.39, n.3, pp.203-206. ISSN 1678-4774. http://dx.doi.org/10.1590/S1676-24442003000300004.
Alcoholism is related to malnutrition and low levels of several vitamins that take part in the metabolism of homocystein (HCY). The objective of this study was to analyse the prevalence of hyperhomocysteinaemia in patients with heavy daily intake of sugar-cane liquor. In this study were included 31 hospitalized man for alcoholism treatment. Serum folate (FOL), HCY, vitamin B12 (B12) and liver enzymes were determinated and repeated after 21 days of alcohol withdrawal. The values of HCY in µmol/l before and after treatment were respectivally of 24.88 ± 2.09 and 12.48 ± 0.69. The alcohol abstinence decreased significativally the values of aspartate transaminase, alanine aminotransferase and gamma-glutamyl transpeptidase. There were not alterations in red blood cell count, total protein and hemoglobin corpuscular media concentration. The levels of HCY before treatment are correlated to the FOL (r 2 = 0.333). These results suggested that chronic alcoholism is followed by disturbs of sulphur aminoacid metabolism and that the hyperhomocysteinaemia ethanol-induced by sugar-cane liquor may be accompanied by low serum FOL levels that aggrieves the nutritional status of these patients.
Keywords : Homocystein; Folate; Alcoholism.