Jornal Brasileiro de Patologia e Medicina Laboratorial
Print version ISSN 1676-2444
GALLE, Leonilda Chiari and GIANINNI, Maria José Soares Mendes. Prevalence and susceptibility of vaginal yeast. J. Bras. Patol. Med. Lab. [online]. 2004, vol.40, n.4, pp. 229-236. ISSN 1676-2444. http://dx.doi.org/10.1590/S1676-24442004000400004.
Among the vulvovaginitis, candidiasis is the most frequent cause in women at reprodutive age of and several researches have shownd an increase in the frequency of the species non-albicans, and a great concern with repetitive episodes, as well as its relationship with the resistance to the treatment. OBJECTIVE: The purpose of this study was to verify the yeast species that cause vaginitis and their susceptibility to antifungal agents. MATERIAL AND METHOD: Vaginal swabs were colleted from 250 patients and were evaluated for culture, species identification and susceptibility to antifungal agents. RESULTS: Candida was present in 27.6% of the samples. Candida albicans was the predominant species (74%), followed by Candida glabrata (14.5%), Candida tropicalis (7,3%) and Candida parapsilosis (4,3%). All the C. albicans isolates were susceptible to anfotericin B and only one sample of non-albicans showed greater MIC (2mg/mL). 5.9% of C. albicans strains were susceptible-dose dependent to FLU and 9,8% resistant. Only one sample showed resistance to itraconazol, with CIM 8mg/mL. In the species non-albicans, 11.8% of the isolates were considered resistant to fluconazol and 23.5% to itraconazol. CONCLUSION: Candida albicans is the most frequent in the vaginal microenviroment, however non-albicans are common vaginal isolates even in a primary care population. The species isolated are less susceptible to fluconazole and itraconazole than most C. albicans, showing the importance of the performance of the identification tests and susceptibility to antifungal agents of vulvovaginal candidiasis.
Keywords : Candidiasis; Vaginal fluid; Antifungal agents susceptibility.