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Jornal Brasileiro de Patologia e Medicina Laboratorial

On-line version ISSN 1678-4774

Abstract

LIMA, Luciana Moreira et al. High-sensitivity C-reactive protein in patients with angiographically defined coronary artery disease. J. Bras. Patol. Med. Lab. [online]. 2007, vol.43, n.2, pp.83-86. ISSN 1678-4774.  http://dx.doi.org/10.1590/S1676-24442007000200003.

C-reactive protein (CPR) is an acute phase protein, synthesized by the liver in response to cytokines, and reflects active inflammation. Inflammation has a potential role in atherosclerosis triggering and progression. Plasma markers of chronic inflammation have been consistently associated to the risk of coronary artery disease (CAD), being high-sensitivity C-reactive protein the marker most studied. The aim of the present study was to determine the high-sensitivity C-reactive protein plasma levels in a group of subjects undergoing coronary angiography, trying to establish a possible correlation between this parameter and the severity of the CAD. High-sensitivity C-reactive protein plasma levels had been determined in blood of 17 subjects with no atheromatosis (controls), 12 subjects presenting mild/moderate atheromatosis and 28 subjects presenting severe atheromatosis, using Biotechnical Reactive C-Protein Turbidimetric Kit with specific high-sensitivity methodology for Cardiology, with linearity to 0.1 up 15mg/l. Significant differences between the means of the three groups were not observed, however the mean values of mild/moderate atheromatosis and severe atheromatosis had remained above the reference values used in Cardiology (0.1-2.5mg/dl). The mean values of the three groups presented an increasing rise from the control group to the severe atherosclerosis, suggesting inflammatory progression due to atherosclerotic injury.

Keywords : Coronary angiography; Coronary artery disease; High-sensitivity C-reactive protein.

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