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Jornal Brasileiro de Patologia e Medicina Laboratorial
On-line version ISSN 1678-4774
KIRSZTAJN, Gianna Mastroianni. Assessment of glomerular filtration rate. J. Bras. Patol. Med. Lab. [online]. 2007, vol.43, n.4, pp.257-264. ISSN 1678-4774. http://dx.doi.org/10.1590/S1676-24442007000400007.
Glomerular filtration rate (GFR) determination is the most frequently used laboratorial test to evaluate renal function. Indirect markers as blood determination of creatinine and cystatin C are used with this purpose, as well as the direct determination of GFR, with indicators like inulin; iodated contrasts, radioactive or not; and others. Serum creatinine is the test that is most commonly performed in order to evaluate GFR in the clinical pathology laboratory. However, in some conditions, aiming at the adequate interpretation of the test, the result of serum creatinine must be corrected (by using formulas that include individual characteristics of the subjects). In fact, inulin is still seen as the ideal marker of glomerular filtration, but its use is not directed to clinical practice; then the search for appropriate tests for routine use continues.
Keywords : Glomerular filtration rate; Serum creatinine; Cystatin; Iohexol clearance.