Jornal Brasileiro de Patologia e Medicina Laboratorial
On-line version ISSN 1678-4774
CAMBRUZZI, Eduardo; SOUZA, Thaís Amara da Costa de; SILVEIRA, Luciano Carvalho and MOREIRA, Carlos Fernando dos Santos. Lymphoplasmacyte-rich meningioma: a case report of a rare neoplasm. J. Bras. Patol. Med. Lab. [online]. 2012, vol.48, n.3, pp.223-227. ISSN 1678-4774. http://dx.doi.org/10.1590/S1676-24442012000300012.
Lymphoplasmacyte-rich meningioma (LPM) is a rare variant of meningioma, which is characterized by massive inflammatory cell infiltration and rare meningothelial elements. The authors report the clinicopathological features of a LPM located at the right parietal convexity in a patient with generalized tonic-clonic seizures and paresthesia in the left arm. The surgical specimen consisted of a gray nodule measuring 3.5 × 3 × 1.8 cm. At microscopy, a few epithelioid cells associated with numerous lymphocytes/plasma cells were identified. Positive immunoexpression for epithelial membrane antigen (EMA) and progesterone receptor was found in the epithelioid cells, and positive staining for CD3, CD5 and CD20 in the inflammatory cells. Thus, the diagnosis of LPM was established.
Keywords : Pathology; Immunohistochemistry; Central nervous system; Meningioma; Brain tumors.