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Jornal Brasileiro de Patologia e Medicina Laboratorial

versão impressa ISSN 1676-2444

Resumo

OSORIO, Cynthia Aparecida Bueno Toledo; CHAVES JUNIOR, Marcos Araújo  e  SOARES, Fernando Augusto. Assessment of pathological response in breast cancer after neoadjuvant chemotherapy: standardization of adapted protocol. J. Bras. Patol. Med. Lab. [online]. 2012, vol.48, n.6, pp.447-453. ISSN 1676-2444.  http://dx.doi.org/10.1590/S1676-24442012000600010.

The concept of pathologic complete response (pCR) is controversial. Previous studies used different methods of pCR assessment, but there is no universal consensus about the best protocol for the study of surgical specimens from patients with breast carcinoma undergoing neoadjuvant chemotherapy. Symmans et al. developed a classification system of residual cancer burden (RCB) after neoadjuvant chemotherapy for breast cancer analyzing the extent of primary tumor bed, the percentage of residual viable tumor cells in the tumor bed and lymph node involvement. We present a proposal for the evaluation of pathological response in breast tumors after neoadjuvant chemotherapy. Based on Symmans et al. study, it consists in a protocol adapted to our routine pathological examination of surgical specimens.

Palavras-chave : Breast cancer; Neoadjuvant chemotherapy; Pathological response; Protocol.

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